- Sean Thomas Gerard Pop, Dream Pop, Indie
- Second Chance Rock, Beach, Soul
- Second Line Stompers Jazz, New Orleans Jazz
- Secret Monkey Weekend Rock, Roots Rock, Swampy Guitar
- Secretary Pool Rock, Indie Rock
- See Gulls Pop, Punk, 90\'s
- See No Weevil Blues, R&B, Rock
- Seth Brand Acoustic, Rock, Pop
- Several Devils Band Rock, Indie, Soul
- Sezessionville Road Americana, Alternative Rock, Indie
- SGS13 Rock, Classic Rock
- Shadowhawk Bluegrass Band Bluegrass
- Shady Darling and the Velvet Curtain Blues, Soul, Jazz
- Shady Hill Acoustic
- Shaggie Maggie Blues, Rhythm, Rock
- Shakedown Street Rock, Grateful Dead Tribute
- Shaketown Rock, Pop/Rock
- Shame for Sydney Rock, Acoustic Rock, Pop, Country Rock
- Shanachie Folk, Celtic, Irish Folk
- Shane Bullis Folk, Rock, Hip-Hop
- Shane David Rock, Americana
- Shane Smith Rock, Americana, Country
- Shane W. Dittmar Acoustic, Singer-Songwriter
- Shannon Baker and Sometime Soon Bluegrass, Gospel, Folk
- Shannon O'Connor Americana
- Sharing Secrets Folk
- Shark Quest Acoustic, Instrumental
- She Bop Rock, Pop, 80\'s Tribute
- She's Buyin Rock, Folk, Country
- Sheila Casalett Jazz
- Sheila Fleming Folk
- Shelby Merchant Country, Singer-Songwriter, R&B, Pop
- SHELL SHOCK Rock, Metal
- Shelter Rock
- Shenette Jones R&B, Singer-Songwriter, Soul
- Sherman Lee Dillon Blues, Roots, Singer-Songwriter
- Sherman Neckties Rock, Alternative Rock
- Sheyenne Rivers Pop, Electronica, Rock
- Shiloh Hill Americana, Folk, Pop
- Shine Rock, Dance, Pop, Southern Rock
- Shonna R&B, Soul
- Shoot 2 Thrill Rock, AC/DC Tribute, Blues, Classic Rock
- Shot Time and Cigarettes Rock, Southern Rock
- Shotgun Mary Country
- Shoulda Known Better Rock, Country, Classic Rock
- Sibannac Rock, Alternative, Punk, Ska
- Sidecar Social Club Jazz
- Sideline Bluegrass
- Sidetrac Band Country, Country Rock, Rock, Blues
- Sidewalk Babes Pop, Garage Rock, Surf
- Silverfox
- Silverscreen Orchestra and the Jitters
- Simone Finally Folk
- Simplified Rock, Acoustic, Reggae
- Sincerely, Iris Folk, Acoustic, Rock
- Sinners and Saints Folk, Alternative Country
- Siren Rock, Hard Rock
- Siren Radio Pop, Dance, Alternative, Rock
- SIRSY Rock, Pop, Soul
- Sissy Brown Country, Honky Tonk
- Sissy Pants Rock, Pop
- Six Pack Cadillac Rock, Blues, R&B, Motown
- Six Shots Later Rock, Alternative, pop-funk
- Six Stylez Rock, Pop, Dance
- Sixteen Penny Rock, Southern Rock, Classic Rock, Country
- Skavinjir Rock, Hard Rock
- Skee-Town Stylee Hip-Hop/Rap, Alternative, Reggae, Dub
- Skintight Rock
- Skullduggery Blues, Garage Punk, Rock & Roll, Classic Rock
- SkyCresT Rock, Alternative, Metal
- Skye Bradley
- Skylark and The Siren Folk, Country, Soul
- SlapJacket Rock, Country, Alternative, Dance
- Sleeping Booty Rock, Pop, R&B
- Sleeping Policeman Rock, Indie, Blues
- Slide Band Pop, Rock
- Slinger Francisco Rock, Indie Rock
- Slingshot Cash Country, Sleazy, Appalachian Rock, Americana
- Slippery When Wet Hair Metal, Rock & Roll
- Slow Down For Poetry Acoustic, Folk
- Small House Jazz
- Small Town Gossip Folk, Pop, Acoustic
- Smashed Cardinals Rock, Acoustic, Country, Soul
- smile R&B, Disco, Funk, Soul
- Smith and Lang Acoustic, Soft Rock
- Smitty and The Jumpstarters Blues
- Smoke From All the Friction Pop, Dark pop, indie electronic, Rock
- Smonder Island Rock, Indie, Jam Rock
- SNAKEWIG Rock
- SnapBack Country
- Social Contracts Rock
- Soggy Po’ Boys Jazz, New Orleans Jazz
- Solar Bear Rock, Pop, Variety
- Something Acoustic Pop, Rock, Country
- Sonic Jones Rock
- Sonja Viajero
- Sons of Paradise Hip-Hop/Rap, Reggae, Rock
- Sons of the South Bluegrass Band Bluegrass
- SoPoz Rock, Jam Rock, Reggae
- SOUL DeCREE R&B, Soul
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